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Restoring testosterone rather than replacing it helps safeguard a man's fertility October 27, 2015 Restoring testosterone production in men may be as effective as replacing it, without compromising their fertility. In a study published December 22 in Stem Cell Reports,... Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism.
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Restoring testosterone rather than replacing it helps safeguard a man's fertility October 27, 2015 Restoring testosterone production in men may be as effective as replacing it, without compromising their fertility. US opioid use not declined, despite focus on abuse and awareness of risk August 1, 2018 Use of prescription opioids in the United States has not substantially declined over the last decade, despite increased attention to opioid abuse and awareness of their risks, finds a study published by The BMJ today. What is more of a concern, they note, is using the drug for longer periods of time.

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The researchers note that while compensated hypogonadism can cause a temporary reduction in the production of sperm cells , reducing fertility, it is generally not cause for alarm. In a study published December 22 in Stem Cell Reports,... Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown.

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This effect was also observed in a human steroidogenic cell line. In a study published December 22 in Stem Cell Reports,... Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression.

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